Consulting services for early stage biotechnology companies.
Antibody discovery and engineering solutions from early stage antibody discovery, overall molecular design, engineering for superior manufacturing and drug like properties, and design and selection of your final clinical candidate. We can help you partner directly with CROs to meet your exact needs for the full lifecycle of antibody discovery and engineering.
Adapted from Brezski and Georgiou. Immunoglobulin isotype knowledge and application to Fc engineering.
Services
Antibody Discovery
Identify and collaborate with select CROs for both phage display as well as in vivo discovery in hosts like mice, rabbits, or chickens
Antigen design and immunization strategies
Proven success for designing strategies for hybridoma, B cell sorting, NGS, and other discovery platforms
Antibody Engineering
Fit-for-purpose design of the overall biologic-based scaffold
Isotype selection and modulation of effector function through Fc engineering
Half-life extension
Educational Seminars
Can provide custom educational seminars from high level antibody engineering overview to more specific topics like antibody humanization, engineering for good drug-like properties, selection of a multi-specific platform, and Fc engineering
Computational Antibody Engineering
For open-source, Python-based sequence, structure, or AI/ML computational analysis packages, I can obtain files from GitHub and run antibody and/or protein design analyses via local execution without the need to use web servers
Custom Python code for identifying chemical and physical liabilities in antibody sequences
Custom Python code for full antibody sequence annotation and alignment
Antibody and Fc Fusion Proteins
Whole antibody, Fc, and antibody fragment fusion protein designs
Linker design for fusion proteins
Humanization
Hundreds of humanized antibodies from multiple species
Design strategies for simultaneous humanization and CDR editing to remove chemical and biophysical liabilities
Multi-Specific Engineering
Can help you identify the right engineering strategies to design multi-specific antibody-based molecules. Help identify the right CROs to meet your multi-specific expression and purification needs
Antibody Expression and Purification
Design large panels of antibodies, fusion proteins, or antigens for antibody discovery and help you identify the right CRO to quickly go from designs on paper to delivered proteins to seamlessly integrate into new or existing antibody development workflows
Let’s get started!
From early antibody discovery through final clinical candidate selection, we can help you design antibody discovery campaigns, select CROs to meet your individual needs, help manage CRO workflows, and design and deliver final antibody-based molecular candidates for clinical development.